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Outcome [edit] The primary results of the pathway are: The generation of reducing equivalents, in the form of NADPH, used in reductive biosynthesis reactions within cells (e.g

revealed that in breast cancer mouse model, MCT inhibitor Syrosingopine downregulated the number of Treg cell and upregulated that of NK cells and M1 phenotype of TAM, suggesting reversal of the immunosuppressive TME

And the modulatory rather than stimulatory nature of its effects on systems like nitric oxide and inflammation suggests a lower risk of overcorrection compared to directionally-acting compounds

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